SREBF1 Antikörper (N-Term)
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- Target Alle SREBF1 Antikörper anzeigen
- SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Maus, Rind (Kuh), Ziege, Pferd, Meerschweinchen, Kaninchen, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SREBF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- AGRGRANGLD APRAGADRGA MDCTFEDMLQ LINNQDSDFP GLFDPPYAGS
- Homologie
- Cow: 93%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SREBF1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human SREBF1
- Top Product
- Discover our top product SREBF1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1177 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
- Andere Bezeichnung
- SREBF1 (SREBF1 Produkte)
- Synonyme
- SREBP-1c antikoerper, SREBP1 antikoerper, bHLHd1 antikoerper, ADD-1 antikoerper, ADD1 antikoerper, D630008H06 antikoerper, SREBP-1 antikoerper, SREBP-1a antikoerper, SREBP1c antikoerper, Srebp1 antikoerper, SCREBP1 antikoerper, SREBP-1C antikoerper, SREBF1 antikoerper, srebp1 antikoerper, sterol regulatory element binding transcription factor 1 antikoerper, sterol regulatory element binding transcription factor 1 L homeolog antikoerper, sterol regulatory element binding protein-1 antikoerper, Sterol regulatory element Binding Protein antikoerper, SREBF1 antikoerper, Srebf1 antikoerper, srebf1.L antikoerper, SREBP-1 antikoerper, srebf1 antikoerper, sbp-1 antikoerper
- Hintergrund
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SREBF1is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: SREBP1, bHLHd1, SREBP-1c
Protein Interaction Partner: UBC, ERLIN2, FBXW7, SMARCD3, HSP90AA1, SUMO1, ATXN1L, INSIG2, SCAP, ATXN1, LMNA, INSIG1, EGF, SREBF2, SREBF1, ZBTB7A, ZBTB7C, SUMO2, MED6, MED13, MED12, MED24, MED26, MED17, MED23, MED14, USF1, MED1, GSK3B, CREBBP, CDK8, MED25, MED15, MED7, MED21, SIRT1,
Protein Size: 1177 - Molekulargewicht
- 125 kDa
- Gen-ID
- 6720
- NCBI Accession
- NM_001005291, NP_001005291
- Pathways
- AMPK Signaling, Caspase Kaskade in der Apoptose, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
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