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RCAN1 Antikörper (Middle Region)

RCAN1 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Schaf, Kaninchen, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2780590
  • Target Alle RCAN1 Antikörper anzeigen
    RCAN1 (Regulator of Calcineurin 1 (RCAN1))
    Bindungsspezifität
    • 15
    • 11
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 78
    • 19
    • 17
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Schaf, Kaninchen, Zebrafisch (Danio rerio)
    Wirt
    • 73
    • 5
    • 1
    Kaninchen
    Klonalität
    • 77
    • 2
    Polyklonal
    Konjugat
    • 38
    • 7
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RCAN1 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 38
    • 13
    • 13
    • 9
    • 8
    • 7
    • 3
    • 3
    • 2
    Western Blotting (WB)
    Sequenz
    PVINYDLLYA ISKLGPGEKY ELHAATDTTP SVVVHVCESD QEKEEEEEME
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 79%
    Produktmerkmale
    This is a rabbit polyclonal antibody against RCAN1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human RCAN1
    Top Product
    Discover our top product RCAN1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 252 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Voronov, Ochotny, Jaumouillé, Owen, Manolson, Aubin: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).

  • Target
    RCAN1 (Regulator of Calcineurin 1 (RCAN1))
    Andere Bezeichnung
    RCAN1 (RCAN1 Produkte)
    Synonyme
    ADAPT78 antikoerper, CSP1 antikoerper, DSC1 antikoerper, DSCR1 antikoerper, MCIP1 antikoerper, RCN1 antikoerper, RCAN1 antikoerper, 2410048A02Rik antikoerper, AA408855 antikoerper, AI429645 antikoerper, AL024459 antikoerper, AV028423 antikoerper, Adapt78 antikoerper, CALP1L antikoerper, Dscr1 antikoerper, Mcip1 antikoerper, dscr1 antikoerper, rcan1 antikoerper, wu:fr92c05 antikoerper, adapt78 antikoerper, csp1 antikoerper, dsc1 antikoerper, mcip1 antikoerper, MGC53636 antikoerper, rcn1 antikoerper, MGC69428 antikoerper, regulator of calcineurin 1 antikoerper, regulator of calcineurin 1b antikoerper, regulator of calcineurin 1 L homeolog antikoerper, Down syndrome critical region gene 1 antikoerper, RCAN1 antikoerper, Rcan1 antikoerper, rcan1b antikoerper, rcan1.L antikoerper, dscr1 antikoerper, rcan1 antikoerper
    Hintergrund
    RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
    Alias Symbols: ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
    Protein Interaction Partner: UBC, PPP3CA, NEDD8, APP, FBXW11, BTRC, FBXW4, TOLLIP, TRAF6, IRAK1, HSP90AA1, STAT2, GSK3B, MAP3K3, MAPK3, UXT,
    Protein Size: 252
    Molekulargewicht
    28 kDa
    Gen-ID
    1827
    NCBI Accession
    NM_004414, NP_004405
    UniProt
    P53805
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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