FGD1 Antikörper (N-Term)

Produktnummer ABIN2780596

Produktdetails anti-FGD1 Antikörper

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Bindungsspezifität: N-Term

Reaktivität: Human, Rind (Kuh), Schwein, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: HGHRAPGGAG PSEPEHPATN PPGAAPPACA DSDPGASEPG LLARRGSGSA

Homologie: Cow: 86%, Human: 100%, Pig: 86%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against FGD1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 961 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FGD1 Antikörper (ABIN2780596)

Zou, Greenblatt, Shim, Kant, Zhai, Lotinun, Brady, Hu, Gygi, Baron, Davis, Jones, Glimcher: "MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice." in: The Journal of clinical investigation, Vol. 121, Issue 11, pp. 4383-92, (2011) (PubMed).

Details zu FGD1

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Andere Bezeichnung: FGD1 (FGD1 Produkte)

Synonyme: AAS antikoerper, FGDY antikoerper, MRXS16 antikoerper, ZFYVE3 antikoerper, FYVE, RhoGEF and PH domain containing 1 antikoerper, FGD1 antikoerper, Fgd1 antikoerper, fgd1 antikoerper

Hintergrund: FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AAS, FGDY, ZFYVE3, MRXS16
Protein Interaction Partner: BTRC, UBC, ELAVL1, ELMO1, CTTN, CDC42, AOC1,
Protein Size: 961

Molekulargewicht: 106 kDa

Gen-ID: 2245

NCBI Accession: NM_004463, NP_004454

UniProt: P98174

Pathways: Neurotrophin Signalübertragung