HMGN1 Antikörper (Middle Region)

Produktnummer ABIN2780630

Produktdetails anti-HMGN1 Antikörper

Target: HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 93%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against HMGN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HMGN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 100 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HMGN1 Antikörper (ABIN2780630)

Lane, Chapuy, Lin, Tivey, Li, Townsend, van Bodegom, Day, Wu, Liu, Yoda, Alexe, Schinzel, Sullivan, Malinge, Taylor, Stegmaier, Jaffe, Bustin, te Kronnie, Izraeli, Harris, Stevenson, Neuberg et al.: "Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. ..." in: Nature genetics, Vol. 46, Issue 6, pp. 618-23, (2014) (PubMed).

Details zu HMGN1

Target: HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))

Andere Bezeichnung: HMGN1 (HMGN1 Produkte)

Synonyme: HMG14 antikoerper, hmg14 antikoerper, hmgn1 antikoerper, hmgn1b antikoerper, HMG-14 antikoerper, Hmg14 antikoerper, high mobility group nucleosome binding domain 1 antikoerper, high mobility group nucleosome binding domain 1 S homeolog antikoerper, high mobility group nucleosomal binding domain 1 antikoerper, non-histone chromosomal protein HMG-14 antikoerper, HMGN1 antikoerper, hmgn1.S antikoerper, hmgn1 antikoerper, Hmgn1 antikoerper, LOC785479 antikoerper

Hintergrund: Chromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ27265, FLJ31471, HMG14, MGC104230, MGC117425
Protein Interaction Partner: UBC, RPS6KA3, PRKCA, PRKACG, SLC38A3, PPP1CC, LIG4, PPIP5K1, TERF2, SPP1, POLR2A, ERCC8, HDGF, EP300, BTG2, ERCC6, NFE2, RPS6KA5, RPS6KA4, PRKACA, YWHAZ, HMGN1, HMGN2, IRF2,
Protein Size: 100

Molekulargewicht: 11 kDa

Gen-ID: 3150

NCBI Accession: NM_004965, NP_004956

UniProt: Q6NSG7

Pathways: Chromatin Binding