NRF1 Antikörper (N-Term)

Produktnummer ABIN2780635

Produktdetails anti-NRF1 Antikörper

Target: NRF1 (Nuclear Respiratory Factor 1 (NRF1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen, Zebrafisch (Danio rerio), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NRF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against NRF1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NRF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 503 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NRF1

Target: NRF1 (Nuclear Respiratory Factor 1 (NRF1))

Andere Bezeichnung: NRF1 (NRF1 Produkte)

Synonyme: ALPHA-PAL antikoerper, C87038 antikoerper, D6Ertd415e antikoerper, SC:BZ3C13.1 antikoerper, SC:bZ3C13.2 antikoerper, ube2h antikoerper, Nfe2l1_retired antikoerper, IBR/F antikoerper, NRF1 antikoerper, alpha-pal antikoerper, nrf-1 antikoerper, LOC100220087 antikoerper, nuclear respiratory factor 1 antikoerper, nuclear respiratory factor 1 S homeolog antikoerper, NRF1 antikoerper, Nrf1 antikoerper, nrf1 antikoerper, nrf1.S antikoerper

Hintergrund: NRF1 is a phosphorylated nuclear protein with a bZIP domain. This protein homodimerizes and functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
Alias Symbols: ALPHA-PAL
Protein Interaction Partner: POGZ, TRAF2, SP4, FHL2, DYNLL1, CSNK2B, CSNK2A1, UBC, HHV8GK18_gp81, CEBPB, PARP1, PPRC1, MAFF, PPARGC1A, Dynlt1b, CDK1, MRPL57, TFAM,
Protein Size: 503

Molekulargewicht: 53 kDa

Gen-ID: 4899

NCBI Accession: NM_005011, NP_005002

UniProt: Q16656

Pathways: Regulation of Lipid Metabolism by PPARalpha