ETS2 Antikörper (Middle Region)

Produktnummer ABIN2780665

Produktdetails anti-ETS2 Antikörper

Target: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Schaf, Ziege, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ETS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DPDEVARRWG KRKNKPKMNY EKLSRGLRYY YDKNIIHKTS GKRYVYRFVC

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ETS2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ETS2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 469 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ETS2

Target: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Andere Bezeichnung: ETS2 (ETS2 Produkte)

Synonyme: 0123/09 antikoerper, 0608/07 antikoerper, 0998/12 antikoerper, 3520 antikoerper, CG17077 antikoerper, CG8705 antikoerper, D-Ets-2 antikoerper, D-ets-2 antikoerper, DMPOINT1A antikoerper, Dmel\\CG17077 antikoerper, E(E2F)3D antikoerper, EK3-2 antikoerper, ETS2 antikoerper, EY3-1 antikoerper, Ets antikoerper, Ets2 antikoerper, Ets58AB antikoerper, Ets94F antikoerper, PNT-P1 antikoerper, PNTP1 antikoerper, PNTP2 antikoerper, POINT antikoerper, Pnt antikoerper, Pnt-P1 antikoerper, PntP1 antikoerper, PntP2 antikoerper, Pointed-P1 antikoerper, ets94F antikoerper, l(3)07825 antikoerper, l(3)j1B7 antikoerper, l(3)s118306 antikoerper, png antikoerper, pnt-P1 antikoerper, pnt-P2 antikoerper, pntP2 antikoerper, pntegfr antikoerper, pointed-RC antikoerper, ptd antikoerper, zgc:92106 antikoerper, wu:fe02h08 antikoerper, wu:fk74c05 antikoerper, AU022856 antikoerper, Ets-2 antikoerper, ETS2IT1 antikoerper, c-ets-2 antikoerper, pointed antikoerper, v-ets avian erythroblastosis virus E26 oncogene homolog 2 antikoerper, E26 avian leukemia oncogene 2, 3' domain antikoerper, ETS proto-oncogene 2, transcription factor antikoerper, pnt antikoerper, ets2 antikoerper, Ets2 antikoerper, ETS2 antikoerper

Hintergrund: ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ETS2IT1
Protein Interaction Partner: UBC, RFWD2, TWIST1, POU5F1, TWIST2, ZFYVE9, SRA1, XPO1, TP53, SUMO2, EP300, CREBBP, NCOR1, NCOA3, SRC, ZMYND11, TDP2, STAT5B, CDK10, SMARCA4, JUN, ERG, ETS2, ETS1, NR3C1, GATA3, FOS, SPI1, BRCA1,
Protein Size: 469

Molekulargewicht: 53 kDa

Gen-ID: 2114

NCBI Accession: NM_005239, NP_005230

UniProt: P15036

Pathways: EGFR Signaling Pathway, Myometrial Relaxation and Contraction