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SIX Homeobox 1 Antikörper (N-Term)

SIX1 Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Schaf, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2780732
  • Target Alle SIX Homeobox 1 (SIX1) Antikörper anzeigen
    SIX Homeobox 1 (SIX1)
    Bindungsspezifität
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 31
    • 20
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Schaf, Zebrafisch (Danio rerio)
    Wirt
    • 27
    • 4
    Kaninchen
    Klonalität
    • 28
    • 3
    Polyklonal
    Konjugat
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIX Homeobox 1 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 14
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    ERLGRFLWSL PACDHLHKNE SVLKAKAVVA FHRGNFRELY KILESHQFSP
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against Six1. It was validated on Western Blot.
    Aufreinigung
    Affinity Purified
    Top Product
    Discover our top product SIX1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 284 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SIX Homeobox 1 (SIX1)
    Andere Bezeichnung
    Six1 (SIX1 Produkte)
    Synonyme
    BOS3 antikoerper, DFNA23 antikoerper, TIP39 antikoerper, BB138287 antikoerper, six1b antikoerper, six2 antikoerper, zgc:92332 antikoerper, XSix1 antikoerper, six1 antikoerper, zgc:77345 antikoerper, SIX homeobox 1 antikoerper, sine oculis-related homeobox 1 antikoerper, SIX homeobox 1a antikoerper, SIX homeobox 1 L homeolog antikoerper, SIX homeobox 1b antikoerper, SIX1 antikoerper, Six1 antikoerper, six1a antikoerper, six1.L antikoerper, six1b antikoerper
    Hintergrund
    Six1 is a transcription factor that is involved in regulation of organogenesis. It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation. It may be involved in limb tendon and ligament development. It binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter. It is thought to be regulated by association with Dach and Eya proteins. Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex. During myogenesis, Six1 seems to act together with EYA2 and DACH2 .
    Alias Symbols: BB138287
    Protein Interaction Partner: Eya4, Eya1, Smarca4, Neurog1, Neurod1, Smarcc2, Sox2, Smarcc1, Eya3, Dach1,
    Protein Size: 284
    Molekulargewicht
    32 kDa
    Gen-ID
    20471
    NCBI Accession
    NM_009189, NP_033215
    UniProt
    Q62231
    Pathways
    Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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