HBP1 Antikörper (Middle Region)

Produktnummer ABIN2780873

Produktdetails anti-HBP1 Antikörper

Target: HBP1 (HMG Box-Containing Protein 1 (HBP1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SVILGDRWKK MKNEERRMYT LEAKALAEEQ KRLNPDCWKR KRTNSGSQQH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against HBP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HBP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 514 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HBP1 Antikörper (ABIN2780873)

Wang, Pan, Chen, Huang, Zhang: "The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression." in: Nucleic acids research, Vol. 40, Issue 3, pp. 981-95, (2012) (PubMed).

Li, Bian, Liao, Li, Zhao: "miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1." in: Breast cancer research and treatment, Vol. 126, Issue 3, pp. 565-75, (2011) (PubMed).

Details zu HBP1

Target: HBP1 (HMG Box-Containing Protein 1 (HBP1))

Andere Bezeichnung: HBP1 (HBP1 Produkte)

Synonyme: 1700058O05Rik antikoerper, BE629963 antikoerper, C330012F01Rik antikoerper, C86454 antikoerper, hbp1-B antikoerper, Hmgb1 antikoerper, wu:fj62c10 antikoerper, zgc:112297 antikoerper, high mobility group box transcription factor 1 antikoerper, HMG-box transcription factor 1 antikoerper, HMG-box transcription factor 1 L homeolog antikoerper, Hbp1 antikoerper, HBP1 antikoerper, hbp1.L antikoerper, hbp1 antikoerper

Hintergrund: HBP1 is a transcriptional repressor that binds to the promoter region of target genes. This protein plays a role in the regulation of the cell cycle and of the Wnt pathway. It binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter, HBP1 is enhanced by interaction with RB1. The protein also can disrupt the interaction between DNA and TCF4.
Alias Symbols: FLJ16340
Protein Interaction Partner: FBXW11, UBC, TMEM37, SMAD1, ZNF212, KIAA1279, EWSR1, CD2AP, EP300, CREBBP, MYC, ANKRD2, SIN3A, SAP30, TCF4, HDAC1, RBL2, RB1,
Protein Size: 514

Molekulargewicht: 58 kDa

Gen-ID: 26959

NCBI Accession: NM_012257, NP_036389

UniProt: O60381