CNOT7 Antikörper (N-Term)

Produktnummer ABIN2780900

Der Kaninchen Polyklonal Anti-CNOT7-Antikörper wurde für WB und IHC validiert. Er ist geeignet, CNOT7 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Pferd, Kaninchen, Meerschweinchen, Ziege und Saccharomyces cerevisiae zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für CNOT7 Antikörper (N-Term) (ABIN2780900)

Target: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7 (CNOT7))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Pferd, Kaninchen, Meerschweinchen, Ziege, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNOT7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CNOT7 Antikörper

Bindungsspezifität: N-Term

Sequenz: TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CNOT7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CNOT7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 262 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CNOT7 Antikörper (ABIN2780900)

Maragozidis, Karangeli, Labrou, Dimoulou, Papaspyrou, Salataj, Pournaras, Matsouka, Gourgoulianis, Balatsos: "Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker." in: Acta haematologica, Vol. 128, Issue 1, pp. 39-46, (2012) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Details zu CNOT7

Target: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7 (CNOT7))

Andere Bezeichnung: CNOT7

Hintergrund: CNOT7 binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs.The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Alias Symbols: CAF1, hCAF-1
Protein Interaction Partner: FBXW11, TOB2, BTG2, FOXC2, UBC, BAG3, CNOT6, AGO2, AGO1, EPAS1, APP, ELAVL1, BTG1, Cnot3, HOXD4, IKBKG, BTG3, TOB1, CDK6, CDK4, CDK2, CDK1, PABPC1,
Protein Size: 262

Molekulargewicht: 30 kDa

Gen-ID: 29883

NCBI Accession: NM_013354, NP_037486

UniProt: Q9UIV1

Pathways: Ribonucleoprotein Complex Subunit Organization