UBR1 Antikörper (N-Term)

Produktnummer ABIN2781277

Produktdetails anti-UBR1 Antikörper

Target: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YKQLQKEYIS DDHDRSISIT ALSVQMFTVP TLARHLIEEQ NVISVITETL

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Yeast: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against UBR1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UBR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1749 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-UBR1 Antikörper (ABIN2781277)

Yamaguchi, Moritani, Tanahashi, Osabe, Nomura, Fujita, Keshavarz, Kunika, Nakamura, Yoshikawa, Ichiishi, Shiota, Yasui, Inoue, Itakura: "Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population." in: BMC medical genetics, Vol. 9, pp. 22, (2008) (PubMed).

Details zu UBR1

Target: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Andere Bezeichnung: UBR1 (UBR1 Produkte)

Synonyme: Dmel\\CG9086 antikoerper, Ubr1 antikoerper, UBR1 antikoerper, JBS antikoerper, AI504731 antikoerper, RGD1562326 antikoerper, Ubr1 ubiquitin ligase antikoerper, ubiquitin protein ligase E3 component n-recognin 1 antikoerper, E3 ubiquitin-protein ligase ubr-1 antikoerper, Ubr1 antikoerper, ubr1 antikoerper, UBR1 antikoerper, ubr-1 antikoerper

Hintergrund: UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: JBS, MGC142065, MGC142067
Protein Interaction Partner: CDC6, UBC, SHFM1, UBE2D1, CBX8, ZNF593, DNPH1, USP5, XPO1, PFAS, CSE1L, ATP6V1A, VCL, UCHL3, CUL2, RECQL4, TIRAP, DNAJB11, NUDT3, SPRY2, LAMTOR3, UBE2A, GSK3B, GADD45A, BCL2L1, UBE2Z, NSFL1C, UBXN1, UBXN7, FAF2, FAF1, FOS, HNRNPA1, NDUFA4L2, ARL15, BTBD2,
Protein Size: 1749

Molekulargewicht: 200 kDa

Gen-ID: 197131

NCBI Accession: NM_174916, NP_777576

UniProt: Q8IWV7