Neuregulin 1 Antikörper (Middle Region)
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- Target Alle Neuregulin 1 (NRG1) Antikörper anzeigen
- Neuregulin 1 (NRG1)
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Rind (Kuh), Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Neuregulin 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- SEVQVTVQGD KAVVSFEPSA APTPKNRIFA FSFLPSTAPS FPSPTRNPEV
- Homologie
- Cow: 91%, Guinea Pig: 91%, Human: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against NRG1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human NRG1
- Top Product
- Discover our top product NRG1 Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Neuregulin 1 (NRG1)
- Andere Bezeichnung
- NRG1 (NRG1 Produkte)
- Synonyme
- 6030402G23Rik antikoerper, ARIA antikoerper, D230005F13Rik antikoerper, GGF antikoerper, GGFII antikoerper, HRG antikoerper, HRGalpha antikoerper, Hgl antikoerper, NDF antikoerper, SMDF antikoerper, GGF2 antikoerper, HGL antikoerper, HRG1 antikoerper, HRGA antikoerper, MST131 antikoerper, NRG-1 antikoerper, heregulin antikoerper, nrg1-A antikoerper, pro-neuregulin-1 antikoerper, NRG1 antikoerper, wu:fm70e01 antikoerper, DKFZp459A1838 antikoerper, neuregulin 1 antikoerper, histidine rich glycoprotein antikoerper, neuregulin 1 L homeolog antikoerper, Nrg1 antikoerper, NRG1 antikoerper, HRG antikoerper, nrg1.L antikoerper, nrg1 antikoerper
- Hintergrund
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Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
Alias Symbols: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF, MST131
Protein Interaction Partner: IKZF4, ADAM19, LIMK1, ERBB4, ERBB3, EGF, EGFR, ERBB2, DLG4,
Protein Size: 296 - Molekulargewicht
- 32 kDa
- Gen-ID
- 3084
- NCBI Accession
- NM_013959, NP_039253
- UniProt
- Q15491
- Pathways
- RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation
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