CBP Antikörper (N-Term)

Produktnummer ABIN2781491

Produktdetails anti-CBP Antikörper

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: TPAASQALNP QAQKQVGLAT SSPATSQTGP GICMNANFNQ THPGLLNSNS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CREBBP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CREBBP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2404 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CBP

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Andere Bezeichnung: CREBBP (CREBBP Produkte)

Synonyme: CBP antikoerper, KAT3A antikoerper, RSTS antikoerper, AW558298 antikoerper, CBP/p300 antikoerper, p300/CBP antikoerper, RTS antikoerper, cbp antikoerper, crebbp antikoerper, kat3a antikoerper, rsts antikoerper, hmm291030 antikoerper, Nejire antikoerper, CREB binding protein antikoerper, CREB binding protein L homeolog antikoerper, histone acetyltransferase p300 antikoerper, CREBBP antikoerper, Crebbp antikoerper, crebbp.L antikoerper, LOC100123220 antikoerper

Hintergrund: CREBBP is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.
Alias Symbols: CBP, KAT3A, RSTS, RTS
Protein Interaction Partner: SUMO1, UBE2I, UBE2D1, TDG, RELA, CREBBP, KLF2, KLF4, WRN, PSME3, COPS2, UBC, BMI1, EID1, ATF4, DYRK1B, DYRK1A, ATF2, CREB1, CDK2, JUN, PPARG, IRF3, HNF4A, KLF1, vIRF-3, AR, vIRF-1, CNTN2, SMAD3, SMAD2, LDLR, STAT1, K8, MTDH, MEIS1, TLR2, EPAS1, MYBL1, LIG
Protein Size: 2404

Molekulargewicht: 261 kDa

Gen-ID: 1387

NCBI Accession: NM_001079846, NP_001073315

UniProt: Q4LE28

Pathways: T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha