G6PC Antikörper (N-Term)

Produktnummer ABIN2781770

Produktdetails anti-G6PC Antikörper

Target: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser G6PC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: NLVFKWILFG QRPYWWVLDT DYYSNTSVPL IKQFPVTCET GPGSPSGHAM

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against G6PC. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human G6PC

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 357 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and may contain up to 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-G6PC Antikörper (ABIN2781770)

Iwasa, Kobayashi, Mifuji-Moroka, Hara, Miyachi, Sugimoto, Tanaka, Fujita, Gabazza, Takei: "Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis." in: PLoS ONE, Vol. 8, Issue 7, pp. e70309, (2013) (PubMed).

Details zu G6PC

Target: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Andere Bezeichnung: G6PC (G6PC Produkte)

Synonyme: AW107337 antikoerper, G6Pase antikoerper, G6pt antikoerper, Glc-6-Pase antikoerper, G6PC1 antikoerper, G6PT antikoerper, GSD1 antikoerper, GSD1a antikoerper, G-6-Pase antikoerper, glucose-6-phosphatase, catalytic antikoerper, glucose-6-phosphatase catalytic subunit antikoerper, glucose-6-phosphatase, catalytic subunit antikoerper, G6pc antikoerper, G6PC antikoerper

Hintergrund: G6PC hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum.It forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: G6PT, GSD1a, MGC163350, GSD1, G6PC1
Protein Interaction Partner: NSL1, SNX13, CDH16, FOXO1,
Protein Size: 357

Molekulargewicht: 40 kDa

Gen-ID: 2538

NCBI Accession: NM_000151, NP_000142

UniProt: P35575

Pathways: Carbohydrate Homeostasis, Cellular Glucan Metabolic Process