CPT1A Antikörper (Middle Region)
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- Target Alle CPT1A Antikörper anzeigen
- CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Pferd, Kaninchen, Schaf, Zebrafisch (Danio rerio), Hund, Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CPT1A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- LSTSQTPQQQ VELFDLENNP EYVSSGGGFG PVADDGYGVS YILVGENLIN
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against CPT1A. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CPT1A
- Top Product
- Discover our top product CPT1A Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 756 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity." in: European journal of medicinal chemistry, Vol. 127, pp. 379-397, (2017) (PubMed).
: "The contribution of the citrate pathway to oxidative stress in Down syndrome." in: Immunology, Vol. 149, Issue 4, pp. 423-431, (2016) (PubMed).
: "New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor ?/? dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression." in: Journal of medicinal chemistry, Vol. 56, Issue 1, pp. 60-72, (2013) (PubMed).
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New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity." in: European journal of medicinal chemistry, Vol. 127, pp. 379-397, (2017) (PubMed).
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- Target
- CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))
- Andere Bezeichnung
- CPT1A (CPT1A Produkte)
- Synonyme
- MGC53498 antikoerper, CPT1 antikoerper, CPT1-L antikoerper, L-CPT1 antikoerper, L-CPTI antikoerper, si:dkey-56p7.8 antikoerper, C730027G07 antikoerper, CPTI antikoerper, Cpt1 antikoerper, CPT-Ia antikoerper, carnitine palmitoyltransferase 1A (liver) L homeolog antikoerper, carnitine palmitoyltransferase 1A antikoerper, carnitine palmitoyltransferase 1A (liver) antikoerper, carnitine palmitoyltransferase 1Aa (liver) antikoerper, carnitine palmitoyltransferase 1a, liver antikoerper, cpt1a.L antikoerper, CPT1A antikoerper, cpt1a antikoerper, cpt1aa antikoerper, Cpt1a antikoerper
- Hintergrund
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The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CPT1, CPT1-L, L-CPT1
Protein Interaction Partner: UBC, SUMO2, LGR4, RNF2, FBXO6, PARK2, LYN, CLN3, HDAC11, KBTBD7, NPDC1, HSPA5, NR4A1, CYBA, CLIC1, SNRNP200, ERLIN1, TOMM40, EIF3C, PCBP1, NDUFV1, NDUFS1, NDUFA2, LPP, CPS1, ATP6V1C1, RHOA, PCK1, BCL2,
Protein Size: 756 - Molekulargewicht
- 86 kDa
- Gen-ID
- 1374
- NCBI Accession
- NM_001031847, NP_001027017
- UniProt
- P50416
- Pathways
- AMPK Signaling, Regulation of Lipid Metabolism by PPARalpha, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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