Patched 2 Antikörper (N-Term)

Produktnummer ABIN2782247

Produktdetails anti-Patched 2 Antikörper

Target: Patched 2 (PTCH2)

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LAQEALPENA SQQIHAFSST TLDDILHAFS EVSAARVVGG YLLMLAYACV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PTCH2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PTCH2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1203 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Patched 2

Target: Patched 2 (PTCH2)

Andere Bezeichnung: PTCH2 (PTCH2 Produkte)

Synonyme: PTC2 antikoerper, ptc2 antikoerper, Ptch1 antikoerper, ptc-2 antikoerper, xptc-2 antikoerper, xptch-2 antikoerper, patched-2 antikoerper, ptch2 antikoerper, ptc-1 antikoerper, ptc1 antikoerper, ptch1 antikoerper, patched 2 antikoerper, patched 2 S homeolog antikoerper, patched 2 L homeolog antikoerper, PTCH2 antikoerper, Ptch2 antikoerper, ptch2.S antikoerper, ptch2.L antikoerper, ptch2 antikoerper

Hintergrund: PTCH2 is a member of the patched protein family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. The gene encoding PTCH2 is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. This gene encodes a member of the patched gene family. The patched protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. This gene is shown to be mutated in a medulloblastoma and in a basal cell carcinoma, suggesting that it plays a role in the development of some tumors. Alternative transcript variants have been described, but their biological function has not been determined. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-10 AF119569.1 1-10 11-534 AY359016.1 3-526 535-2066 AF087651.1 523-2054 2067-2509 AF119569.1 2067-2509 2510-2520 AF087651.1 2498-2508 2521-2700 AF119569.1 2521-2700 2701-3620 AY358555.1 2689-3608 3621-3624 AF087651.1 3609-3612
Alias Symbols: PTC2
Protein Interaction Partner: ARRB1, DHH, SMO, IHH, SHH,
Protein Size: 1203

Molekulargewicht: 130 kDa

Gen-ID: 8643

NCBI Accession: NM_003738, NP_003729

UniProt: Q9Y6C5

Pathways: Hedgehog Signalweg