SBDS Antikörper (N-Term)

Produktnummer ABIN2782336

Produktdetails anti-SBDS Antikörper

Target: SBDS (Shwachman-Bodian-Diamond Syndrome (SBDS))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Zebrafisch (Danio rerio), Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SBDS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against SBDS. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SBDS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 250 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SBDS Antikörper (ABIN2782336)

Sezgin, Henson, Nihrane, Singh, Wattenberg, Alard, Ellis, Liu: "Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS." in: Pediatric blood & cancer, Vol. 60, Issue 2, pp. 281-6, (2012) (PubMed).

Details zu SBDS

Target: SBDS (Shwachman-Bodian-Diamond Syndrome (SBDS))

Andere Bezeichnung: SBDS (SBDS Produkte)

Synonyme: cgi-97 antikoerper, sds antikoerper, swds antikoerper, zgc:56700 antikoerper, SDS antikoerper, SWDS antikoerper, 4733401P19Rik antikoerper, AI836084 antikoerper, CGI-97 antikoerper, SBDS ribosome assembly guanine nucleotide exchange factor antikoerper, hypothetical protein antikoerper, SBDS, ribosome maturation factor antikoerper, SBDS ribosome assembly guanine nucleotide exchange factor S homeolog antikoerper, SBDS ribosome maturation factor antikoerper, sbds antikoerper, LOAG_04440 antikoerper, sbds.S antikoerper, SBDS antikoerper, Sbds antikoerper

Hintergrund: SBDS is a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The protein may function in RNA metabolism. Mutations within its gene are associated with Shwachman-Bodian-Diamond syndrome.This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.
Alias Symbols: CGI-97, FLJ10917, SDS, SWDS
Protein Interaction Partner: SUMO2, TYMS, PNP, IDH1, GOT1, UBC, CHAMP1, MPLKIP, MRPL53, SARNP, SLIRP, SRPRB, ACOT13, SRRM2, TIMM44, TOMM40, UBE4B, SCO2, SNX3, STX7, SF1, VDAC3, TIAL1, SPR, RBMS1, NDUFA7, NDUFA2, IDH3G, STOM, ACAA1, ACD, TERF2IP, POT1, TERF1, CLN3,
Protein Size: 250

Molekulargewicht: 28 kDa

Gen-ID: 51119

NCBI Accession: NM_016038, NP_057122

UniProt: Q9Y3A5

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly