CSTB Antikörper (Middle Region)

Produktnummer ABIN2782349

Produktdetails anti-CSTB Antikörper

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Pferd, Schwein, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSTB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: AGTNYFIKVH VGDEDFVHLR VFQSLPHENK PLTLSNYQTN KAKHDELTYF

Homologie: Dog: 92%, Horse: 85%, Human: 100%, Mouse: 83%, Pig: 79%, Rabbit: 77%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CSTB. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CSTB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 98 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CSTB

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Andere Bezeichnung: CSTB (CSTB Produkte)

Hintergrund: CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Alias Symbols: CST6, EPM1, PME, STFB, ULD, EPM1A
Protein Interaction Partner: UBC, SARNP, DPP7, BAG3, CFTR, ECT2, SEC24A, NUDC, MAT2A, FLNB, DCUN1D1, CUL3, RAD21, SPRY2, CTSL, CTSD, CTSH, CTSB, CST3, VHL,
Protein Size: 98

Molekulargewicht: 11 kDa

Gen-ID: 1476

NCBI Accession: NM_000100, NP_000091

UniProt: P04080

Pathways: Response to Water Deprivation