RMI1 Antikörper (N-Term)

Produktnummer ABIN2782588

Produktdetails anti-RMI1 Antikörper

Target: RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RMI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DGILEIPKGE LNGFYALQIN SLVDVSQPAY SQIQKLRGKN TTNDLVTAEA

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against RMI1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RMI1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 625 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RMI1

Target: RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))

Andere Bezeichnung: RMI1 (RMI1 Produkte)

Hintergrund: RMI1 is an essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. RMI1 promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. RMI1 is required for BLM phosphorylation during mitosis. Within the BLM complex, RMI1 is required for BLM and TOP3A stability.RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-136 BP327553.1 1-136 137-885 DN997105.1 9-757 886-2740 AL732446.4 14777-16631 2741-3508 BC039999.2 2566-3333
Alias Symbols: BLAP75, C9orf76, FLJ12888, RP11-346I8.1
Protein Interaction Partner: APITD1, STRA13, UBC, RPA3, RPA2, RPA1, TOPBP1, BLM, NR1H2, UBE3A, HSPA13, PFDN1, Ercc6l, Top3a, FANCM, RMI2, FANCF, RMI1, FANCA,
Protein Size: 625

Molekulargewicht: 70 kDa

Gen-ID: 80010

NCBI Accession: NM_024945, NP_079221

UniProt: Q9H9A7

Pathways: DNA Reparatur