DCC Antikörper (Middle Region)
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- Target Alle DCC Antikörper anzeigen
- DCC (Deleted in Colorectal Carcinoma (DCC))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Kaninchen, Pferd, Zebrafisch (Danio rerio), Hund, Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DCC Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- PIGQMHPPHG SVTPQKNSNL LVIIVVTVGV ITVLVVVIVA VICTRRSSAQ
- Homologie
- Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against DCC. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human DCC
- Top Product
- Discover our top product DCC Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1447 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- DCC (Deleted in Colorectal Carcinoma (DCC))
- Andere Bezeichnung
- DCC (DCC Produkte)
- Synonyme
- CRC18 antikoerper, CRCR1 antikoerper, IGDCC1 antikoerper, MRMV1 antikoerper, DCC antikoerper, zdcc antikoerper, C030036D22Rik antikoerper, Igdcc1 antikoerper, xdcc antikoerper, XDCCa antikoerper, dcca-A antikoerper, Dcc antikoerper, DCC netrin 1 receptor antikoerper, deleted in colorectal carcinoma antikoerper, netrin receptor DCC antikoerper, DCC antikoerper, dcc antikoerper, Dcc antikoerper, LOC100712666 antikoerper
- Hintergrund
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This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Alias Symbols: CRC18, CRCR1, IGDCC1
Protein Interaction Partner: UBC, ALB, BARD1, sina, UBI4, SIAH2, EIF4E3, EIF2A, EIF5A2, NTN1, RPL23, EIF2S2, EIF2B2, EIF2B4, EZR, RPS24, RPS13, RPS10, RPS6, RPS4X, RPL38, RPL28, RPL13, RPL5, PTK2, MAPK1, RPL10A, EIF3E, EIF4E, EIF2S3, EIF2B1, EIF1AX, ADORA2B, APPL1, CASP9, SIAH1, MAPK
Protein Size: 1447 - Molekulargewicht
- 158 kDa
- Gen-ID
- 1630
- NCBI Accession
- NM_005215, NP_005206
- UniProt
- P43146
- Pathways
- Regulation of Cell Size
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