NOX1 Antikörper (C-Term)

Produktnummer ABIN2782754

Produktdetails anti-NOX1 Antikörper

Target: NOX1 (NADPH Oxidase 1 (NOX1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Pferd, Zebrafisch (Danio rerio), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: STIATSHPKS VVGVFLCGPR TLAKSLRKCC HRYSSLDPRK VQFYFNKENF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against NOX1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NOX1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 564 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NOX1 Antikörper (ABIN2782754)

Rayegan, Dehpour, Sharifi: "Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase." in: Metabolic brain disease, Vol. 32, Issue 1, pp. 41-49, (2016) (PubMed).

Kuwano, Kawahara, Yamamoto, Teshima-Kondo, Tominaga, Masuda, Kishi, Morita, Rokutan: "Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells." in: American journal of physiology. Cell physiology, Vol. 290, Issue 2, pp. C433-43, (2006) (PubMed).

Details zu NOX1

Target: NOX1 (NADPH Oxidase 1 (NOX1))

Andere Bezeichnung: NOX1 (NOX1 Produkte)

Synonyme: GP91-2 antikoerper, MOX1 antikoerper, NOH-1 antikoerper, NOH1 antikoerper, NOX1a antikoerper, NOX1alpha antikoerper, Nox-1 antikoerper, Nox1 antikoerper, NADPH oxidase 1 antikoerper, NOX1 antikoerper, Nox1 antikoerper, nox1 antikoerper

Hintergrund: Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox.Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. The NOH-1S currents were reversibly blocked by zinc, a known H+ channel inhibitor. The NOH-1S variant does not contain an electron transport chain and it is thought that H+ conductance is its main physiologic function, whereas NOH-1L may conduct H+ ions as part of its electron transport mechanism.
Alias Symbols: GP91-2, MOX1, NOH-1, NOH1
Protein Interaction Partner: NOXA1, CYBA,
Protein Size: 564

Molekulargewicht: 65 kDa

Gen-ID: 27035

NCBI Accession: NM_007052, NP_008983

UniProt: Q9Y5S8

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Proton Transport