NAGPA Antikörper (N-Term)

Produktnummer ABIN2782884

Produktdetails anti-NAGPA Antikörper

Target: NAGPA (N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))

Bindungsspezifität: N-Term

Reaktivität: Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Ratte, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAGPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GECLGNVVSD ERRVSSSGGL QNAQFGIRRD GTLVTGYLSE EEVLDTENPF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against NAGPA. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human NAGPA

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NAGPA

Target: NAGPA (N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))

Andere Bezeichnung: NAGPA (NAGPA Produkte)

Synonyme: NAGPA antikoerper, APAA antikoerper, UCE antikoerper, AI596180 antikoerper, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase antikoerper, NAGPA antikoerper, NAEGRDRAFT_56913 antikoerper, Nagpa antikoerper

Hintergrund: Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.
Alias Symbols: APAA, UCE
Protein Interaction Partner: ZHX2, DEGS1, NAGPA, EPS15, AP2A1, FURIN,
Protein Size: 515

Molekulargewicht: 53 kDa

Gen-ID: 51172

NCBI Accession: NM_016256, NP_057340

UniProt: Q9UK23