PPP1R13B Antikörper (Middle Region)

Produktnummer ABIN2783179

Produktdetails anti-PPP1R13B Antikörper

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1R13B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EFDLVQRIIY EVEDPSKPND EGITPLHNAV CAGHHHIVKF LLDFGVNVNA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PPP1R13B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PPP1R13B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1090 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PPP1R13B

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Andere Bezeichnung: PPP1R13B (PPP1R13B Produkte)

Synonyme: ASPP1 antikoerper, p53BP2-like antikoerper, p85 antikoerper, AI449786 antikoerper, AW545810 antikoerper, Tp53bp2 antikoerper, Trp53bp2 antikoerper, protein phosphatase 1 regulatory subunit 13B antikoerper, protein phosphatase 1, regulatory subunit 13B antikoerper, protein phosphatase 1 regulatory subunit 13B L homeolog antikoerper, protein phosphatase 1, regulatory subunit 13Bb antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 13B antikoerper, PPP1R13B antikoerper, Ppp1r13b antikoerper, ppp1r13b.L antikoerper, ppp1r13bb antikoerper, ppp1r13b antikoerper

Hintergrund: PPP1R13B is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Alias Symbols: ASPP1, KIAA0771, p53BP2-like, p85
Protein Interaction Partner: TRAF1, CCDC184, MIPOL1, LATS2, SIAH2, PPP1CC, PPP1CA, HRAS, LATS1, KHDRBS1, ERBB2, CEP63, TNIK, CDC5L, UBC, PLEKHA5, APC, TP63, TP73, E2F4, E2F3, E2F2, E2F1,
Protein Size: 1090

Molekulargewicht: 119 kDa

Gen-ID: 23368

NCBI Accession: NM_015316, NP_056131

UniProt: Q96KQ4

Pathways: p53 Signalweg