REC8 Antikörper (N-Term)

Produktnummer ABIN2783199

Produktdetails anti-REC8 Antikörper

Target: REC8 (REC8 Homolog (Yeast) (REC8))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser REC8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QLQIGVIRVY SQQCQYLVED IQHILERLHR AQLQIRIDME TELPSLLLPN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against REC8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human REC8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 547 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu REC8

Target: REC8 (REC8 Homolog (Yeast) (REC8))

Andere Bezeichnung: REC8 (REC8 Produkte)

Synonyme: Rec8L1 antikoerper, mrec antikoerper, HR21spB antikoerper, REC8L1 antikoerper, Rec8p antikoerper, REC8 meiotic recombination protein antikoerper, REC8 homolog (yeast) antikoerper, REC8 antikoerper, Rec8 antikoerper

Hintergrund: REC8 is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
Alias Symbols: HR21spB, MGC950, REC8L1, Rec8p
Protein Interaction Partner: SYCP3, SMC3, SMC1A,
Protein Size: 547

Molekulargewicht: 62 kDa

Gen-ID: 9985

NCBI Accession: NM_005132, NP_005123

UniProt: O95072