Selenoprotein S Antikörper (Middle Region)

Produktnummer ABIN2783218

Produktdetails anti-Selenoprotein S Antikörper

Target: Selenoprotein S (SELS)

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Ziege, Meerschweinchen, Pferd, Kaninchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Selenoprotein S Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PDVVVKRQEA LAAARLKMQE ELNAQVEKHK EKLKQLEEEK RRQKIEMWDS

Homologie: Cow: 93%, Dog: 86%, Goat: 75%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 93%, Yeast: 90%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SELS. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SELS

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 189 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Selenoprotein S Antikörper (ABIN2783218)

Du, Liu, Huang: "Influence of SelS gene silence on beta-Mercaptoethanol-mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells." in: Biochimica et biophysica acta, Vol. 1800, Issue 5, pp. 511-7, (2010) (PubMed).

Moses, Johnson, Tømmerdal, Forsmo, Curran, Abraham, Charlesworth, Brennecke, Blangero, Austgulen: "Genetic association of preeclampsia to the inflammatory response gene SEPS1." in: American journal of obstetrics and gynecology, Vol. 198, Issue 3, pp. 336.e1-5, (2008) (PubMed).

Zeng, Du, Zhou, Huang: "Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells." in: Archives of biochemistry and biophysics, Vol. 478, Issue 1, pp. 1-6, (2008) (PubMed).

Details zu Selenoprotein S

Target: Selenoprotein S (SELS)

Andere Bezeichnung: SELS (SELS Produkte)

Synonyme: ADO15 antikoerper, SBBI8 antikoerper, SELS antikoerper, SEPS1 antikoerper, 1500011E07Rik antikoerper, C78786 antikoerper, H-4 antikoerper, H-47 antikoerper, H4 antikoerper, H47 antikoerper, Sels antikoerper, sg2 antikoerper, selenoprotein S antikoerper, SELENOS antikoerper, Selenos antikoerper

Hintergrund: SELS is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alias Symbols: AD-015, ADO15, MGC104346, MGC2553, SBBI8, SEPS1, VIMP, SELS
Protein Interaction Partner: UBC, SRPK2, PTGS2, CAV1, DERL2, APOB, DERL1, VCP, KPNB1, AMFR, SYVN1, HERPUD1, SAA1, SVIP, NPLOC4, UFD1L, HSPA4,
Protein Size: 189

Molekulargewicht: 21 kDa

Gen-ID: 55829

NCBI Accession: NM_018445, NP_060915

UniProt: Q9BQE4

Pathways: Cellular Response to Molecule of Bacterial Origin, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom