PDHA1 Antikörper (C-Term)

Produktnummer ABIN2783236

Produktdetails anti-PDHA1 Antikörper

Target: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Zebrafisch (Danio rerio), Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDHA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against PDHA1. It was validated on Western Blot using a cell lysate as a positive control.

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PDHA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 390 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PDHA1

Target: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Andere Bezeichnung: PDHA1 (PDHA1 Produkte)

Synonyme: PDHA antikoerper, PDHCE1A antikoerper, PHE1A antikoerper, Pdha-1 antikoerper, pdha antikoerper, phe1a antikoerper, pdhce1a antikoerper, im:6895726 antikoerper, pdha1 antikoerper, wu:fd18b01 antikoerper, wu:fo96f03 antikoerper, zgc:73271 antikoerper, zgc:86692 antikoerper, Pdha1 antikoerper, wu:fp73b04 antikoerper, zgc:92705 antikoerper, NI36_05250 antikoerper, pdha1-a antikoerper, pdha1-b antikoerper, pyruvate dehydrogenase E1 alpha 1 subunit antikoerper, pyruvate dehydrogenase E1 alpha 1 antikoerper, pyruvate dehydrogenase (lipoamide) alpha 1 antikoerper, pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene antikoerper, 2-oxo acid dehydrogenase antikoerper, pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha antikoerper, pyruvate dehydrogenase alpha subunit protein antikoerper, pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit antikoerper, precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit antikoerper, pyruvate dehydrogenase antikoerper, pyruvate dehydrogenase E1 alpha 1 subunit a antikoerper, pyruvate dehydrogenase E1 alpha 1 subunit b antikoerper, pyruvate dehydrogenase E1 component subunit alpha antikoerper, pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog antikoerper, PDHA1 antikoerper, Pdha1 antikoerper, pdha1 antikoerper, LOC719277 antikoerper, VNG_RS07485 antikoerper, RR_RS04695 antikoerper, pdhA1 antikoerper, pdha1a antikoerper, pdha1b antikoerper, NI36_RS05240 antikoerper, pdha1.S antikoerper

Hintergrund: The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1), dihydrolipoyl transacetylase (DLAT), and dihydrolipoyl dehydrogenase (DLD). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex.The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1), dihydrolipoyl transacetylase (DLAT, MIM 608770) (E2, EC 2.3.1.12), and dihydrolipoyl dehydrogenase (DLD, MIM 238331) (E3, EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PDHA, PDHCE1A, PHE1A
Protein Interaction Partner: HUWE1, SUMO2, UBC, GINS4, DCPS, NCDN, VCL, PPP1R2, MSN, ASL, ADRB2, ITGA4, HNRNPDL, PDHX, SDHA, PDHB, OGDH, GTF2I, DLAT, CUL3, SIRT7, ATG101, WDR20, BABAM1, USP19, PDP1, EIF6, PDK4, PDK3, PDK2, PDK1, PDHA1, DGKE,
Protein Size: 390

Molekulargewicht: 40 kDa

Gen-ID: 5160

NCBI Accession: NM_000284, NP_000275

UniProt: P08559

Pathways: Warburg Effekt