BAG3 Antikörper (Middle Region)

Produktnummer ABIN502922

Produktdetails anti-BAG3 Antikörper

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Kaninchen, Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NVTRPAAQPS FHQAQKTHYP AQQGEYQTHQ PVYHKIQGDD WEPRPLRAAS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against BAG3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BAG3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 575 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BAG3

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Andere Bezeichnung: BAG3 (BAG3 Produkte)

Synonyme: bag3-A antikoerper, MGC53113 antikoerper, zgc:100859 antikoerper, BAG3 antikoerper, ATBAG3 antikoerper, BCL-2-associated athanogene 3 antikoerper, T28J14.160 antikoerper, T28J14_160 antikoerper, BAG-3 antikoerper, BIS antikoerper, CAIR-1 antikoerper, MFM6 antikoerper, AA407278 antikoerper, Bis antikoerper, mg638 antikoerper, BCL2 associated athanogene 3 L homeolog antikoerper, BCL2-associated athanogene 3 antikoerper, BCL2 associated athanogene 3 antikoerper, BCL-2-associated athanogene 3 antikoerper, Bcl2-associated athanogene 3 antikoerper, bag3.L antikoerper, bag3 antikoerper, BAG3 antikoerper, Bag3 antikoerper

Hintergrund: BAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BAG-3, BIS, CAIR-1, MGC104307
Protein Interaction Partner: SF3B4, DAZAP2, ARRDC3, LITAF, MAGED1, PDE9A, HSPA8, PHLDB1, HSPB1, HSF1, STUB1, DNAJB6, AMOT, PDLIM7, MLF2, HSPB8, WBP2, UBC, MCM7, HSP90AB1, ETFA, MVP, ACLY, PSAP, PSME1, PSMD12, PSMD9, PSMD8, PSMD5, PSMD3, PSMD2, PSMC5, PSMC3, PSMC2, PSMC1, PSMB5, PSMB4
Protein Size: 575

Molekulargewicht: 61 kDa

Gen-ID: 9531

NCBI Accession: NM_004281, NP_004272

UniProt: O95817