COQ8A Antikörper (N-Term)

Produktnummer ABIN2783345

Produktdetails anti-COQ8A Antikörper

Target: COQ8A (Coenzyme Q8A (COQ8A))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COQ8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FANPRDSFSA MGFQRRFFHQ DQSPVGGLTA EDIEKARQAK ARPENKQHKQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against CABC1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CABC1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 647 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-COQ8A Antikörper (ABIN2783345)

Lagier-Tourenne, Tazir, López, Quinzii, Assoum, Drouot, Busso, Makri, Ali-Pacha, Benhassine, Anheim, Lynch, Thibault, Plewniak, Bianchetti, Tranchant, Poch, DiMauro, Mandel, Barros, Hirano, Koenig: "ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency." in: American journal of human genetics, Vol. 82, Issue 3, pp. 661-72, (2008) (PubMed).

Details zu COQ8A

Target: COQ8A (Coenzyme Q8A (COQ8A))

Andere Bezeichnung: CABC1 (COQ8A Produkte)

Synonyme: ARCA2 antikoerper, CABC1 antikoerper, COQ10D4 antikoerper, COQ8 antikoerper, SCAR9 antikoerper, 4632432J16Rik antikoerper, AI462003 antikoerper, Cabc1 antikoerper, mKIAA0451 antikoerper, cabc1 antikoerper, Adck3 antikoerper, adck4 antikoerper, si:dkey-114g7.2 antikoerper, coenzyme Q8A antikoerper, aarF domain containing kinase 3 antikoerper, coenzyme Q8B antikoerper, COQ8A antikoerper, Coq8a antikoerper, coq8a antikoerper, ADCK3 antikoerper, coq8b antikoerper

Hintergrund: CABC1 is a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis.This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found, however, their full-length nature has not been determined.
Alias Symbols: ADCK3, COQ8, MGC4849, ARCA2, CABC1, SCAR9
Protein Interaction Partner: TMEM239, REEP6, TMEM159, AGTRAP, TFIP11, RABAC1, VCP, UBC, IRAK2, IRAK1, ICT1, COQ8,
Protein Size: 647

Molekulargewicht: 72 kDa

Gen-ID: 56997

NCBI Accession: NM_020247, NP_064632

UniProt: Q8NI60