CHST14 Antikörper (Middle Region)

Produktnummer ABIN2783597

Produktdetails anti-CHST14 Antikörper

Target: CHST14 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 14 (CHST14))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHST14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: REYQQRYGAE IVRRYRAGAG PSPAGDDVTF PEFLRYLVDE DPERMNEHWM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CHST14. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CHST14

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 338 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CHST14 Antikörper (ABIN2783597)

Janecke, Li, Boehm, Krabichler, Rohrbach, Müller, Fuchs, Golas, Katagiri, Ziegler, Gahl, Wilnai, Zoppi, Geller, Giunta, Slavotinek, Steinmann: "The phenotype of the musculocontractural type of Ehlers-Danlos syndrome due to CHST14 mutations." in: American journal of medical genetics. Part A, Vol. 170A, Issue 1, pp. 103-15, (2016) (PubMed).

Details zu CHST14

Target: CHST14 (Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 14 (CHST14))

Andere Bezeichnung: CHST14 (CHST14 Produkte)

Synonyme: ATCS antikoerper, D4ST1 antikoerper, HNK1ST antikoerper, 2600016L03Rik antikoerper, D4ST-1 antikoerper, D4st1 antikoerper, d4st1 antikoerper, MGC136487 antikoerper, wu:fc04a01 antikoerper, zgc:136487 antikoerper, carbohydrate sulfotransferase 14 antikoerper, carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 antikoerper, CHST14 antikoerper, Chst14 antikoerper, chst14 antikoerper

Hintergrund: CHST14 belongs to the sulfotransferase 2 family. CHST14 catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. It transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. It transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. CHST14 has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA.
Alias Symbols: D4ST-1, D4ST1, HD4ST, HNK1ST, ATCS
Protein Interaction Partner: UBD,
Protein Size: 338

Molekulargewicht: 35 kDa

Gen-ID: 113189

UniProt: Q8NCH0

Pathways: Glycosaminoglycan Metabolic Process