SIGIRR Antikörper (C-Term)
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- Target Alle SIGIRR Antikörper anzeigen
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
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Bindungsspezifität
- C-Term
- Reaktivität
- Human, Maus, Ratte, Pferd, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SIGIRR Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SIGIRR. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
- Top Product
- Discover our top product SIGIRR Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 224 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Andere Bezeichnung
- SIGIRR (SIGIRR Produkte)
- Synonyme
- TIR8 antikoerper, AI256711 antikoerper, sc:d148 antikoerper, RGD1306732 antikoerper, single Ig and TIR domain containing antikoerper, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antikoerper, SIGIRR antikoerper, Sigirr antikoerper, sigirr antikoerper
- Hintergrund
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SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
Alias Symbols: MGC110992, TIR8
Protein Interaction Partner: APP, UBC, SIGIRR, TLR9, TLR5, TLR4, TRAF6, IRAK1, RPN1, IL1R1, ENO2,
Protein Size: 224 - Molekulargewicht
- 25 kDa
- Gen-ID
- 59307
- UniProt
- Q6IA17
- Pathways
- Toll-Like Receptors Cascades
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