ULBP1 Antikörper (N-Term)

Produktnummer ABIN2783974

Produktdetails anti-ULBP1 Antikörper

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAAAASPAFL LCLPLLHLLS GWSRAGWVDT HCLCYDFIIT PKSRPEPQWC

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ULBP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ULBP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 244 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ULBP1

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Andere Bezeichnung: ULBP1 (ULBP1 Produkte)

Synonyme: RAET1I antikoerper, A430108B07Rik antikoerper, MULT1 antikoerper, ULBP1 antikoerper, UL16 binding protein 1 antikoerper, UL16 binding protein 21 antikoerper, NKG2D ligand 1 antikoerper, ULBP1 antikoerper, ULBP21 antikoerper, Ulbp1 antikoerper, LOC100683099 antikoerper

Hintergrund: ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Alias Symbols: RAET1I
Protein Interaction Partner: MARCH9, MARCH4, UBC, RAET1G, KLRC4,
Protein Size: 244

Molekulargewicht: 28 kDa

Gen-ID: 80329

NCBI Accession: NM_025218, NP_079494

UniProt: Q9BZM6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process