SIGLEC10 Antikörper (Middle Region)
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- Target Alle SIGLEC10 Antikörper anzeigen
- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SIGLEC10 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- CHVDFSRKGV SAQRTVRLRV AYAPRDLVIS ISRDNTPALE PQPQGNVPYL
- Homologie
- Dog: 79%, Human: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SIGLEC10. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC10
- Top Product
- Discover our top product SIGLEC10 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 697 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." in: Genome biology, Vol. 8, Issue 8, pp. R154, (2008) (PubMed).
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Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." in: Genome biology, Vol. 8, Issue 8, pp. R154, (2008) (PubMed).
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- Target
- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
- Andere Bezeichnung
- SIGLEC10 (SIGLEC10 Produkte)
- Synonyme
- PRO940 antikoerper, SIGLEC-10 antikoerper, SLG2 antikoerper, Siglecg antikoerper, SIGLEC10 antikoerper, slg2 antikoerper, pro940 antikoerper, siglec-10 antikoerper, sialic acid binding Ig like lectin 10 antikoerper, sialic acid binding Ig-like lectin 10 antikoerper, sialic acid-binding Ig-like lectin 10 antikoerper, SIGLEC10 antikoerper, Siglec10 antikoerper, LOC484343 antikoerper, LOC100066644 antikoerper, siglec10 antikoerper, LOC100513863 antikoerper, LOC100340374 antikoerper
- Hintergrund
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SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764
Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2
Protein Interaction Partner: FLNA, PTPN6,
Protein Size: 697 - Molekulargewicht
- 76 kDa
- Gen-ID
- 89790
- NCBI Accession
- NM_033130, NP_149121
- UniProt
- Q96LC7
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