SPOP-B Antikörper (C-Term)

Produktnummer ABIN2784150

Produktdetails anti-SPOP-B Antikörper

Target: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPOP-B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YHASDVLETS GWKSMVVSHP HLVAEAYRSL ASAQCPFLGP PRKRLKQS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPOP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SPOP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 374 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SPOP-B

Target: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Andere Bezeichnung: SPOP (SPOP-B Produkte)

Synonyme: BTBD32 antikoerper, TEF2 antikoerper, AI315626 antikoerper, Pcif1 antikoerper, zgc:64140 antikoerper, spop antikoerper, tef2 antikoerper, speckle type BTB/POZ protein antikoerper, speckle-type POZ protein antikoerper, speckle type POZ protein S homeolog antikoerper, SPOP antikoerper, Spop antikoerper, spop antikoerper, spop.S antikoerper

Hintergrund: SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Alias Symbols: TEF2
Protein Interaction Partner: CUL3, SPOP, DEK, GLI2, AR, ATM, RXRB, MYD88, DAXX, NCOA3, SRRM1, GIT2, FADD, PIAS1, UBC, UBE2E3, PIP4K2B, ESR1, BMI1, RTN3, H2AFY, DPPA2, ZBTB16, HCST, TRAF1, PDX1, DDIT3, TRAF6, SIRT2, DOK2, PIP5K1B, GDI1, KPNA6,
Protein Size: 374

Molekulargewicht: 42 kDa

Gen-ID: 8405

NCBI Accession: NM_001007226, NP_001007227

UniProt: O43791