NUMA1 Antikörper (C-Term)

Produktnummer ABIN503163

Produktdetails anti-NUMA1 Antikörper

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Hund, Rind (Kuh), Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUMA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AQRLQAQLNE LQAQLSQKEQ AAEHYKLQME KAKTHYDAKK QQNQELQEQL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NUMA1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NUMA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2115 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NUMA1 Antikörper (ABIN503163)

Kilpivaara, Rantanen, Tamminen, Aittomäki, Blomqvist, Nevanlinna: "Comprehensive analysis of NuMA variation in breast cancer." in: BMC cancer, Vol. 8, pp. 71, (2008) (PubMed).

Details zu NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Andere Bezeichnung: NUMA1 (NUMA1 Produkte)

Hintergrund: NuMA is a structural element in maintaining nuclear integrity. A critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis. The entire coding region and exon-intron boundaries of NuMa were screened in 92 familial breast cancer patients. But the results do not support the role of NuMA variants as breast cancer susceptibility alleles.
Alias Symbols: NUMA
Protein Interaction Partner: CCDC57, GMCL1, BRAP, DVL3, DVL2, DVL1, UBC, LGR4, ERG, RPA3, RPA2, RPA1, RNF2, EZH2, BMI1, SUZ12, EED, YWHAQ, LMNA, CBX6, WHSC1, HSP90AB1, HSP90AA1, ESR1, CDK6, VCP, SMURF1, MDC1, TP53BP1, ECT2, NCSTN, DDB1, EMILIN1, DYNLL1, RAE1, NUP98, CDK2, TERF2IP, TE
Protein Size: 2115

Molekulargewicht: 238 kDa

Gen-ID: 4926

NCBI Accession: NM_006185, NP_006176

UniProt: Q14980

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, M Phase