SENP6 Antikörper (C-Term)

Produktnummer ABIN2784245

Produktdetails anti-SENP6 Antikörper

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Bindungsspezifität: C-Term

Reaktivität: Human, Rind (Kuh), Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MNLANWFPPP RMRTKREEIR NIILKLQEDQ SKEKRKHKDT YSTEAPLGEG

Homologie: Cow: 79%, Horse: 79%, Human: 100%, Pig: 91%

Produktmerkmale: This is a rabbit polyclonal antibody against SENP6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SENP6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1105 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Andere Bezeichnung: SENP6 (SENP6 Produkte)

Synonyme: SSP1 antikoerper, SUSP1 antikoerper, 2810017C20Rik antikoerper, E130319N12Rik antikoerper, Susp1 antikoerper, mKIAA0797 antikoerper, fc83h02 antikoerper, im:7148342 antikoerper, wu:fc83h02 antikoerper, zgc:171230 antikoerper, SUMO1/sentrin specific peptidase 6 antikoerper, SUMO/sentrin specific peptidase 6 antikoerper, SUMO1/sentrin specific peptidase 6a antikoerper, SENP6 antikoerper, Senp6 antikoerper, senp6a antikoerper

Hintergrund: SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM].
Alias Symbols: FLJ11355, FLJ11887, KIAA0389, KIAA0797, SSP1, SUSP1
Protein Interaction Partner: UBC, SP1, LMNA, COPS5, SUMO2, KAT5, SUMO1, PLA2G2A, RUVBL2, ARNT,
Protein Size: 1105

Molekulargewicht: 125 kDa

Gen-ID: 26054

NCBI Accession: NM_001100409, NP_001093879

UniProt: Q9GZR1