DCLRE1C Antikörper (C-Term)

Produktnummer ABIN406151

Produktdetails anti-DCLRE1C Antikörper

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLRE1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SQSPKLFSDS DGESTHISSQ NSSQSTHITE QGSQGWDSQS DTVLLSSQER

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DCLRE1C. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DCLRE1C

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 572 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DCLRE1C

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Andere Bezeichnung: DCLRE1C (DCLRE1C Produkte)

Hintergrund: DCLRE1C is a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity, it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity, it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).
Alias Symbols: A-SCID, DCLREC1C, FLJ11360, FLJ36438, RS-SCID, SCIDA, SNM1C, hSNM1C
Protein Interaction Partner: XRCC5, PRKDC, RAD50, NBN, MRE11A, BRCA1, ATR, ATM, PSMD9, DDB2, DDB1, FBXW7, TP53BP1,
Protein Size: 572

Molekulargewicht: 65 kDa

Gen-ID: 64421

NCBI Accession: NM_001033857, NP_001029029

UniProt: Q96SD1

Pathways: DNA Reparatur