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CK1 epsilon Antikörper (N-Term)

CSNK1E Reaktivität: Human, Maus, Ratte, Hund, Schaf, Kaninchen, Meerschweinchen, Pferd, Rind (Kuh), Saccharomyces cerevisiae, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2784724
  • Target Alle CK1 epsilon (CSNK1E) Antikörper anzeigen
    CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))
    Bindungsspezifität
    • 13
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 64
    • 38
    • 18
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Schaf, Kaninchen, Meerschweinchen, Pferd, Rind (Kuh), Saccharomyces cerevisiae, Zebrafisch (Danio rerio)
    Wirt
    • 60
    • 8
    • 2
    • 1
    Kaninchen
    Klonalität
    • 63
    • 8
    Polyklonal
    Konjugat
    • 39
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser CK1 epsilon Antikörper ist unkonjugiert
    Applikation
    • 48
    • 34
    • 31
    • 15
    • 11
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 93%, Zebrafish: 93%
    Produktmerkmale
    This is a rabbit polyclonal antibody against CSNK1E. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human CSNK1E
    Top Product
    Discover our top product CSNK1E Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 416 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Levran, Londono, OHara, Nielsen, Peles, Rotrosen, Casadonte, Linzy, Randesi, Ott, Adelson, Kreek: "Genetic susceptibility to heroin addiction: a candidate gene association study." in: Genes, brain, and behavior, Vol. 7, Issue 7, pp. 720-9, (2009) (PubMed).

  • Target
    CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))
    Andere Bezeichnung
    CSNK1E (CSNK1E Produkte)
    Hintergrund
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1E can phosphorylate a large number of proteins. CSNK1E participates in Wnt signaling and is the central component of the circadian clock. It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
    Alias Symbols: HCKIE, MGC10398, CKIepsilon
    Protein Interaction Partner: DVL3, TIAM1, UBC, REST, ZSWIM8, TAZ, SAV1, DVL2, ADAM22, SNX24, AHCYL2, PER1, MCC, HMMR, TCEB2, STK3, SEC13, CSNK1D, CSNK1A1, CRY1, ACACA, FAM83H, FAM83B, VPS13B, FAM199X, KLHDC3, FAM110B, FAM110A, FAM83D, C2orf44, SNX22, STOX2, UNC45A, PPP6R3, WDR5, SDCC
    Protein Size: 416
    Molekulargewicht
    47 kDa
    Gen-ID
    1454
    NCBI Accession
    NM_001894, NP_001885
    UniProt
    P49674
    Pathways
    Hedgehog Signalweg, M Phase
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