COPS8 Antikörper (Middle Region)

Produktnummer ABIN2784840

Produktdetails anti-COPS8 Antikörper

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: TRMVLPRKPV AGALDVSFNK FIPLSEPAPV PPIPNEQQLA RLTDYVAFLE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against COPS8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COPS8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 209 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-COPS8 Antikörper (ABIN2784840)

Pick, Golan, Zimbler, Guo, Sharaby, Tsuge, Hofmann, Wei: "The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain." in: PLoS ONE, Vol. 7, Issue 8, pp. e43980, (2012) (PubMed).

Details zu COPS8

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Andere Bezeichnung: COPS8 (COPS8 Produkte)

Synonyme: COP9 antikoerper, CSN8 antikoerper, SGN8 antikoerper, csn8 antikoerper, cops8 antikoerper, MGC76051 antikoerper, MGC80215 antikoerper, DDBDRAFT_0167123 antikoerper, DDBDRAFT_0233107 antikoerper, DDB_0167123 antikoerper, DDB_0233107 antikoerper, zgc:56319 antikoerper, zgc:86840 antikoerper, MGC86182 antikoerper, 9430009J09Rik antikoerper, AA408242 antikoerper, Csn8 antikoerper, Sgn8 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 9 antikoerper, COP9 SIGNALOSOME SUBUNIT 8 antikoerper, DL3095C antikoerper, EMB143 antikoerper, EMBRYO DEFECTIVE 143 antikoerper, FCAALL.131 antikoerper, FUS7 antikoerper, FUSCA 7 antikoerper, FUSCA PROTEIN FUS7 antikoerper, CG13383 antikoerper, CG33297 antikoerper, CG42522 antikoerper, CH8 antikoerper, Dch8 antikoerper, Dmel\\CG42522 antikoerper, Dmel_CG13383 antikoerper, l(2)SH1829 antikoerper, l(2)SH2 1829 antikoerper, COP9 signalosome subunit 8 antikoerper, COP9 signalosome subunit 8 S homeolog antikoerper, COP9 signalosome complex subunit 8 antikoerper, COP9 signalosome subunit 8 L homeolog antikoerper, COP9 signalosome, subunit CSN8 antikoerper, COPS8 antikoerper, Cops8 antikoerper, cops8 antikoerper, cops8.S antikoerper, CSN8 antikoerper, csn8 antikoerper, cops8.L antikoerper, COP9 antikoerper

Hintergrund: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: COP9, CSN8, MGC1297, MGC43256, SGN8
Protein Interaction Partner: USHBP1, GPS1, cul1, WDR77, SRRT, COPS7A, VIM, COPS4, FBXO6, FBXW4, COPS5, vpr, IRF5, DDIT3, COPS2, COPS3, COPS6, PINK1, RFWD2, CUL4A, UBC, LRR1, DDA1, DDB2, DCUN1D1, VPRBP, CUL2, CUL3, CUL4B, CUL5, NEDD8, JUN, GFER, ERCC8, DDB1, CTNNB1, RAE1, COPS8, EIF3E
Protein Size: 209

Molekulargewicht: 23 kDa

Gen-ID: 10920

NCBI Accession: NM_006710, NP_006701

UniProt: Q99627

Pathways: Zellzyklus