CAPN10 Antikörper (N-Term)

Produktnummer ABIN2784913

Produktdetails anti-CAPN10 Antikörper

Target: CAPN10 (Calpain 10 (CAPN10))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Kaninchen, Hund, Ratte, Meerschweinchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAPN10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CAPN10. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAPN10

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 517 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CAPN10

Target: CAPN10 (Calpain 10 (CAPN10))

Andere Bezeichnung: CAPN10 (CAPN10 Produkte)

Synonyme: CAPN10 antikoerper, CANP10 antikoerper, NIDDM1 antikoerper, AW049679 antikoerper, Capn8 antikoerper, mKIAA1845 antikoerper, calpain 10 antikoerper, calpain 10 L homeolog antikoerper, CAPN10 antikoerper, capn10.L antikoerper, capn10 antikoerper, Capn10 antikoerper

Hintergrund: CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: CANP10, NIDDM1
Protein Interaction Partner: EFNB1, FLOT1, PSMA7, FANCC,
Protein Size: 517

Molekulargewicht: 58 kDa

Gen-ID: 11132

NCBI Accession: NM_023085, NP_075573

UniProt: Q9HC96

Pathways: Positive Regulation of Peptide Hormone Secretion