MLF1 Antikörper (N-Term)
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- Target Alle MLF1 Antikörper anzeigen
- MLF1 (Myeloid Leukemia Factor 1 (MLF1))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte, Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MLF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- GRDLLSISDG RGRAHNRRGH NDGEDSLTHT DVSSFQTMDQ MVSNMRNYMQ
- Homologie
- Human: 100%, Mouse: 79%, Rabbit: 90%, Rat: 79%
- Produktmerkmale
- This is a rabbit polyclonal antibody against MLF1. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human MLF1
- Top Product
- Discover our top product MLF1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 268 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice." in: Journal of the neurological sciences, Vol. 264, Issue 1-2, pp. 77-86, (2007) (PubMed).
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Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice." in: Journal of the neurological sciences, Vol. 264, Issue 1-2, pp. 77-86, (2007) (PubMed).
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- Target
- MLF1 (Myeloid Leukemia Factor 1 (MLF1))
- Andere Bezeichnung
- MLF1 (MLF1 Produkte)
- Hintergrund
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MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. It interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Alias Symbols: -
Protein Interaction Partner: CENPU, COPS3, UBC, NRBP1, YWHAZ, GRIK5, MAGEA11,
Protein Size: 268 - Molekulargewicht
- 29 kDa
- Gen-ID
- 4291
- NCBI Accession
- NM_022443, NP_071888
- UniProt
- P58340
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