Gelsolin Antikörper (C-Term)
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- Target Alle Gelsolin (GSN) Antikörper anzeigen
- Gelsolin (GSN)
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Ratte, Maus, Rind (Kuh), Kaninchen, Hund, Pferd, Schaf, Zebrafisch (Danio rerio), Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Gelsolin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- KPMIIYKGGT SREGGQTAPA STRLFQVRAN SAGATRAVEV LPKAGALNSN
- Homologie
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against GSN. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human GSN
- Top Product
- Discover our top product GSN Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 782 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Ardalan-Shoja-Kiuru syndrome--hereditary gelsolin amyloidosis plus retinitis pigmentosa." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 23, Issue 3, pp. 1071; author reply 1071-2, (2008) (PubMed).
: "
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Ardalan-Shoja-Kiuru syndrome--hereditary gelsolin amyloidosis plus retinitis pigmentosa." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 23, Issue 3, pp. 1071; author reply 1071-2, (2008) (PubMed).
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- Target
- Gelsolin (GSN)
- Andere Bezeichnung
- GSN (GSN Produkte)
- Synonyme
- ADF antikoerper, AGEL antikoerper, CG1106 antikoerper, DGS antikoerper, Dmel\\CG1106 antikoerper, gel antikoerper, scin antikoerper, cb107 antikoerper, gsn antikoerper, sb:cb107 antikoerper, u-gelsolin antikoerper, wu:fi16f06 antikoerper, gelsolin antikoerper, Gelsolin antikoerper, gelsolin S homeolog antikoerper, gelsolin a antikoerper, GSN antikoerper, Gel antikoerper, Gsn antikoerper, gsn.S antikoerper, gsn antikoerper, gsna antikoerper
- Hintergrund
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GSN binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. It is a calcium-regulated protein, which functions in both assembly and disassembly of actin filaments. Defects in the gene encoding GSN are a cause of familial amyloidosis Finnish type (FAF).The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: DKFZp313L0718, ADF, AGEL
Protein Interaction Partner: ITCH, CFLAR, TP53, UBC, CASP3, UBD, FN1, MPG, ESR1, ALB, SDHB, ACTA1, MDM2, UBE2Q2, FBXO25, ARRB2, ARRB1, AR, PSMD4, TNIK, CLIC5, TOM1L1, ACTN4, VDAC1, BCAR1, PXN, LIMK2, VASP, PIK3CG, PTK2B, FHIT, VCL, CSK, APP, ACTB, ACTG1, PLCG1, SRC, PTPN12, PTK2, PIK
Protein Size: 782 - Molekulargewicht
- 83 kDa
- Gen-ID
- 2934
- NCBI Accession
- NM_000177, NP_000168
- UniProt
- P06396
- Pathways
- Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, Autophagie
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