UBE4B Antikörper (N-Term)

Produktnummer ABIN487260

Produktdetails anti-UBE4B Antikörper

Target: UBE4B (Ubiquitin Conjugation Factor E4 B (UBE4B))

Bindungsspezifität: N-Term

Reaktivität: Human, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SPMFCSVASF GASSLSSLYE SSPAPTPSFW SSVPVMGPSL ASPSRAASQL

Homologie: Dog: 79%, Human: 100%, Pig: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against UBE4B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human UBE4B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1302 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UBE4B

Target: UBE4B (Ubiquitin Conjugation Factor E4 B (UBE4B))

Andere Bezeichnung: UBE4B (UBE4B Produkte)

Hintergrund: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B is an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. The gene that encodes the protein is also the strongest candidate in the neuroblastoma tumor suppressor genes. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: E4, HDNB1, KIAA0684, UBOX3, UFD2, UFD2A
Protein Interaction Partner: TRIP12, UBC, FBXW11, HGS, STAM, TP53, MDM2, NUSAP1, NUDCD3, RBM12, PDE3A, CDKN2A, UBL7, UBE2D3, CDC27, TTK, IGBP1, HDLBP, TTC9C, MRPL53, ZFYVE19, SARNP, SRPRB, VPS35, UBA6, VPS29, UFM1, SBDS, VPS36, UBQLN1, UBXN7, UBE2C, AHCYL1, SSSCA1, SF3B4, PPIF, SCO2,
Protein Size: 1302

Molekulargewicht: 146 kDa

Gen-ID: 10277

NCBI Accession: NM_001105562, NP_001099032

UniProt: O95155