Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

GCLM Antikörper (Middle Region)

GCLM Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2785805
  • Target Alle GCLM Antikörper anzeigen
    GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))
    Bindungsspezifität
    • 11
    • 8
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 61
    • 32
    • 24
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)
    Wirt
    • 55
    • 6
    Kaninchen
    Klonalität
    • 49
    • 12
    Polyklonal
    Konjugat
    • 27
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Dieser GCLM Antikörper ist unkonjugiert
    Applikation
    • 36
    • 26
    • 25
    • 18
    • 16
    • 7
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    KPNSNQVNLA SCCVMPPDLT AFAKQFDIQL LTHNDPKELL SEASFQEALQ
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%
    Produktmerkmale
    This is a rabbit polyclonal antibody against GCLM. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human GCLM
    Top Product
    Discover our top product GCLM Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 274 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tomasi, Ryoo, Yang, Iglesias Ara, Ko, Lu: "Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice." in: Free radical biology & medicine, Vol. 68, pp. 148-58, (2014) (PubMed).

    Ramani, Tomasi, Yang, Ko, Lu: "Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis." in: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36341-55, (2012) (PubMed).

  • Target
    GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))
    Andere Bezeichnung
    GCLM (GCLM Produkte)
    Synonyme
    Glclr antikoerper, GLCLR antikoerper, id:ibd3182 antikoerper, wu:fi24c07 antikoerper, zgc:55903 antikoerper, AI649393 antikoerper, Gcmc antikoerper, glutamate-cysteine ligase regulatory subunit antikoerper, glutamate cysteine ligase, modifier subunit antikoerper, glutamate-cysteine ligase modifier subunit antikoerper, glutamate-cysteine ligase, modifier subunit antikoerper, glutamate-cysteine ligase, modifier subunit L homeolog antikoerper, PTRG_09814 antikoerper, Gclm antikoerper, GCLM antikoerper, gclm antikoerper, gclm.L antikoerper
    Hintergrund
    Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: GLCLR
    Protein Interaction Partner: UBC, NAGK, GLRX3, GNAI2, GCLC, STOX1, IRF7, CALM1, SORD, CUL3,
    Protein Size: 274
    Molekulargewicht
    31 kDa
    Gen-ID
    2730
    NCBI Accession
    NM_002061, NP_002052
    UniProt
    P48507
Sie sind hier:
Kundenservice