SPAG8 Antikörper (N-Term)

Produktnummer ABIN2786289

Produktdetails anti-SPAG8 Antikörper

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Bindungsspezifität: N-Term

Reaktivität: Human, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAG8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SGPVLGSSSG AGHGSGSGSG PGCGSVPGSG SGPGPGSGPG SGPGHGSGSH

Homologie: Human: 100%, Rabbit: 86%, Yeast: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SPAG8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPAG8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 501 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SPAG8 Antikörper (ABIN2786289)

Dyrbye, Broholm, Dziegiel, Laursen: "The M129V polymorphism of codon 129 in the prion gene (PRNP) in the Danish population." in: European journal of epidemiology, Vol. 23, Issue 1, pp. 23-7, (2008) (PubMed).

Details zu SPAG8

Target: SPAG8 (Sperm Associated Antigen 8 (SPAG8))

Andere Bezeichnung: SPAG8 (SPAG8 Produkte)

Synonyme: BS-84 antikoerper, HSD-1 antikoerper, SMP1 antikoerper, SPAG3 antikoerper, hSMP-1 antikoerper, MH-SPAG8 antikoerper, sperm associated antigen 8 antikoerper, SPAG8 antikoerper, Spag8 antikoerper

Hintergrund: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. SPAG8 is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
Alias Symbols: BS-84, HSD-1, MGC26201, SMP1, SPAG3, hSMP-1
Protein Interaction Partner: KLHL32, DTX2, SNRPC, CSTF2, PITX1, JMJD4, WHSC1L1, KDM3B, CARM1, PRMT5, PRMT1, PRMT2, RANBP9, UBQLN4, NEDD4L, RAN,
Protein Size: 501

Molekulargewicht: 53 kDa

Gen-ID: 26206

NCBI Accession: NM_172312, NP_758516

UniProt: Q99932