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RHOC Antikörper (N-Term)

RHOC Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Pferd, Saccharomyces cerevisiae, Ziege, Schaf WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2786344
  • Target Alle RHOC Antikörper anzeigen
    RHOC (Ras Homolog Gene Family, Member C (RHOC))
    Bindungsspezifität
    • 9
    • 8
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 42
    • 18
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Pferd, Saccharomyces cerevisiae, Ziege, Schaf
    Wirt
    • 35
    • 8
    Kaninchen
    Klonalität
    • 36
    • 6
    Polyklonal
    Konjugat
    • 22
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RHOC Antikörper ist unkonjugiert
    Applikation
    • 31
    • 26
    • 15
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    VPTVFENYIA DIEVDGKQVE LALWDTAGQE DYDRLRPLSY PDTDVILMCF
    Homologie
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 100%, Zebrafish: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against RHOC. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human RHOC
    Top Product
    Discover our top product RHOC Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 193 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Sousa, Espreafico: "Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets." in: BMC cancer, Vol. 8, pp. 19, (2008) (PubMed).

  • Target
    RHOC (Ras Homolog Gene Family, Member C (RHOC))
    Andere Bezeichnung
    RHOC (RHOC Produkte)
    Synonyme
    ARHC antikoerper, LOC100221682 antikoerper, ARH9 antikoerper, H9 antikoerper, RHOH9 antikoerper, AI324259 antikoerper, Arh9 antikoerper, Arhc antikoerper, CRHOC antikoerper, ras homolog family member C L homeolog antikoerper, ras homolog family member C antikoerper, rhoc.L antikoerper, RHOC antikoerper, rhoc antikoerper, Rhoc antikoerper
    Hintergrund
    RHOC Is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. RHOC is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of RHOC is associated with tumor cell proliferation and metastasis.This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
    Alias Symbols: ARH9, ARHC, H9, MGC1448, MGC61427, RHOH9
    Protein Interaction Partner: FAM65B, UBC, env, ATF2, PPP3CA, CDK2, LNX1, CAV1, CIT, ARHGAP1, RTKN, DIAPH1, ROCK1, VHL, ARHGDIA,
    Protein Size: 193
    Molekulargewicht
    22 kDa
    Gen-ID
    389
    NCBI Accession
    NM_175744, NP_786886
    UniProt
    P08134
    Pathways
    WNT Signalweg, Cell-Cell Junction Organization
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