PPOX Antikörper (N-Term)

Produktnummer ABIN2786509

Produktdetails anti-PPOX Antikörper

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPOX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SSERLGGWIR SVRGPNGAIF ELGPRGIRPA GALGARTLLL VSELGLDSEV

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PPOX. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPOX

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 477 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PPOX Antikörper (ABIN2786509)

de Vooght, van Wijk, van Solinge: "GATA-1 binding sites in exon 1 direct erythroid-specific transcription of PPOX." in: Gene, Vol. 409, Issue 1-2, pp. 83-91, (2008) (PubMed).

Details zu PPOX

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Andere Bezeichnung: PPOX (PPOX Produkte)

Hintergrund: PPOX catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX..This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
Alias Symbols: MGC8485, PPO, V290M, VP
Protein Interaction Partner: HNRNPD, UBC, COPS5, HAP1, PPOX, IMMT,
Protein Size: 477

Molekulargewicht: 51 kDa

Gen-ID: 5498

NCBI Accession: NM_000309, NP_000300

UniProt: P50336

Pathways: Synaptic Membrane, Feeding Behaviour