MVK Antikörper (Middle Region)

Produktnummer ABIN503848

Produktdetails anti-MVK Antikörper

Target: MVK (Mevalonate Kinase (MVK))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Hund, Kaninchen, Zebrafisch (Danio rerio), Schwein, Saccharomyces cerevisiae, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MVK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KEDLELINKW AFQGERMIHG NPSGVDNAVS TWGGALRYHQ GKISSLKRSP

Homologie: Cow: 100%, Dog: 86%, Goat: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against MVK. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MVK

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 396 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MVK

Target: MVK (Mevalonate Kinase (MVK))

Andere Bezeichnung: MVK (MVK Produkte)

Hintergrund: MVK is the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash.This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene.
Alias Symbols: LRBP, MVLK, MK
Protein Interaction Partner: MVK, PPP1CB, GSS, MAT1A, POT1, TERF1, UBC, EWSR1,
Protein Size: 396

Molekulargewicht: 42 kDa

Gen-ID: 4598

NCBI Accession: NM_000431, NP_000422

UniProt: Q03426