RAGE Antikörper (N-Term)

Produktnummer ABIN2786877

Produktdetails anti-RAGE Antikörper

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MKQRFESIEQ VNNLREIQAL RRLNPHPNIL MLHEVVFDRK SGSLALICEL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RAGE. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 419 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-RAGE Antikörper (ABIN2786877)

Tafani, Schito, Pellegrini, Villanova, Marfe, Anwar, Rosa, Indelicato, Fini, Pucci, Russo: "Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B." in: Carcinogenesis, Vol. 32, Issue 8, pp. 1167-75, (2011) (PubMed).

Details zu RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Andere Bezeichnung: RAGE (AGER Produkte)

Hintergrund: RAGE is able to phosphorylate several exogenous substrates and to undergo autophosphorylation.
Alias Symbols: MOK, RAGE1, RAGE, RAGE-1
Protein Interaction Partner: UBC, WDR18, SDF4, HUWE1, ZNF223, MOK, INSR, MAPK6, MYC, JUN, CCNB1,
Protein Size: 419

Molekulargewicht: 48 kDa

Gen-ID: 5891

NCBI Accession: NM_013401, NP_055041

UniProt: Q9UQ07

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteine