Nemo-Like Kinase Antikörper (Middle Region)

Produktnummer ABIN2786944

Produktdetails anti-Nemo-Like Kinase Antikörper

Target: Nemo-Like Kinase (NLK)

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nemo-Like Kinase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against NLK. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NLK

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 527 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Nemo-Like Kinase

Target: Nemo-Like Kinase (NLK)

Andere Bezeichnung: NLK (NLK Produkte)

Synonyme: Amf antikoerper, Gpi1 antikoerper, AI194375 antikoerper, nlk antikoerper, nlkb antikoerper, zgc:111875 antikoerper, Xnlk antikoerper, nlk1 antikoerper, nlk2 antikoerper, NLK antikoerper, nemo-like antikoerper, RGD1561602 antikoerper, glucose-6-phosphate isomerase antikoerper, nemo like kinase antikoerper, nemo-like kinase, type 1 antikoerper, nemo-like kinase L homeolog antikoerper, Nemo-Like kinase antikoerper, nemo-like kinase antikoerper, Gpi antikoerper, NLK antikoerper, Nlk antikoerper, nlk1 antikoerper, nlk.L antikoerper, nlk antikoerper, nemo-like antikoerper

Hintergrund: NLK has a role in cell fate determination, required for differentiation of bone marrow stromal cells. NLK acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. NLK may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP By similarity.NLK is involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
Alias Symbols: DKFZp761G1211, FLJ21033
Protein Interaction Partner: KRTAP5-6, KRTAP10-3, KRTAP4-2, QRICH1, ZHX3, KRTAP5-9, GRN, TP53, MDM2, STAT5A, LEF1, CNOT2, SMAD4, KPNB1, BACH1, TNKS1BP1, FAM222A, C2orf44, CEP97, RNF219, FAM222B, CNOT11, NLK, PASK, SHANK2, UBAP2L, CCP110, TRPS1, TLE3, SKI, RANGAP1, RANBP2, PKM, CNOT3,
Protein Size: 527

Molekulargewicht: 58 kDa

Gen-ID: 51701

NCBI Accession: NM_016231, NP_057315

UniProt: Q9UBE8

Pathways: Ubiquitin Proteasome Pathway