PIDD Antikörper (Middle Region)

Produktnummer ABIN2787144

Produktdetails anti-PIDD Antikörper

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIDD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RRDPEQVLLQ CLPRNKVDAT LRRLLERYRG PEPSDTVEMF EGEEFFAAFE

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against LRDD. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LRDD

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 753 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Andere Bezeichnung: LRDD (PIDD Produkte)

Synonyme: 1200011D09Rik antikoerper, AU042446 antikoerper, Pidd antikoerper, LRDD antikoerper, Lrdd antikoerper, p53 induced death domain protein 1 antikoerper, p53-induced death domain protein 1 antikoerper, Pidd1 antikoerper, PIDD1 antikoerper

Hintergrund: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: DKFZp434D229, MGC16925, PIDD, LRDD
Protein Interaction Partner: CRADD, CRYAB, MDFI, SOX8, KEAP1, TEAD3, MAFG, AFP, RPAP3, FANCI, SENP3, TRIM32, ANP32B, HAX1, TELO2, NUP93, AIFM1, RFC5, RFC4, PRKDC, PPP6C, POLR2B, POLD1, PCNA, PRDX1, MCM7, ERCC5, ERCC2, DDB1, CASP2, FADD, RIPK1, IKBKG, CCDC85B, EFEMP2, MADD,
Protein Size: 753

Molekulargewicht: 83 kDa

Gen-ID: 55367

NCBI Accession: NM_018494, NP_060964

Pathways: p53 Signalweg, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity