PDE8A Antikörper (C-Term)

Produktnummer ABIN2787371

Produktdetails anti-PDE8A Antikörper

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Pferd, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SSNPYHNSTH SADVLHATAY FLSKERIKET LDPIDEVAAL IAATIHDVDH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against PDE8A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PDE8A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 829 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Andere Bezeichnung: PDE8A (PDE8A Produkte)

Synonyme: PDE8A antikoerper, Pde8a antikoerper, HsT19550 antikoerper, AI551852 antikoerper, Pde8 antikoerper, RNPDE8A antikoerper, phosphodiesterase 8A antikoerper, PDE8A antikoerper, Pde8a antikoerper, pde8a antikoerper

Hintergrund: Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000).
Alias Symbols: FLJ16150, HsT19550
Protein Interaction Partner: UBC,
Protein Size: 829

Molekulargewicht: 91 kDa

Gen-ID: 5151

NCBI Accession: NM_002605, NP_002596

UniProt: O60658

Pathways: cAMP Metabolic Process